Active Engines
⚠ T2D engine — MUNCLE-P01 CONFIRMED
Marshall: Metformin 2000mg + Basaglar 50U + Trurapi. Beta cell exhaustion complete. TEMPLE_SCORE building.
⚠ Cardiovascular engine — HIGH PRIOR
Marshall: Rosuvastatin 40mg (high-intensity). Likely prior CV event or very high risk. Downstream of T2D.
⚠ Dyslipidaemia (TG pattern)
Marshall: Fenofibrate 145mg. High TG + low HDL = atherogenic triad. Classic T2D metabolic syndrome.
✓ Dutch grandmother longevity
Marshall mother: almost 100, still alive. Paternal line = durable cellular machinery.
✓ P-WING P02/P03 pending
More paternal uncles needed. Ask Marshall about his brothers to complete the signal.
✓ Prevention window — OPEN
HbA1c + lipids + BP + waist now. Kay has data Marshall never had in time.
⚠ Drug Interactions
HIGH · Cape Flats population prior + Multiple muncle T2D signal
Background population rate + genetic signal = additive. This is a real engine running.
HIGH · T2D + Cardiovascular
Diabetes 2-4x multiplies MI and stroke risk. The CV engine is the one to prevent.
Protocol
Annual HbA1c + fasting glucose
Blood test · Every year from now
T2D signal is strong enough to screen without symptoms. Catch prediabetes early = reversal window open.
Annual lipid panel
Blood test · Every year
LDL + HDL + triglycerides. CV engine is the downstream killer.
Blood pressure monitoring
Home cuff or GP · Every 6 months
Target <130/80. T2D + hypertension = multiplicative CV risk.
Waist circumference
Tape measure · Every 6 months
More predictive than BMI. Target <94cm for males (WHO). Visceral fat = insulin resistance accelerant.
Exercise protocol
150min/week aerobic + 2× resistance · Ongoing
Proven to delay T2D onset by years. Resistance training specifically improves insulin sensitivity.
Dietary protocol
Limit refined carbs + ultra-processed food · Ongoing
Mediterranean-style diet. Not a diet — a pattern. Kay can live his life and still reduce the signal.