| LAYER | SOFTWARE | NEUROSCIENCE | ECONOMICS | ECOLOGY | GOVERNANCE |
|---|---|---|---|---|---|
| L1 | Unit bug | Channelopathy | Bad trade | Species loss | Individual failure |
| L2 | Load failure | Circuit fatigue | Liquidity stress | Habitat degradation | Group dysfunction |
| L3 | Race condition | Network desync | Flash crash | Community cascade | Institutional crisis |
| L4 | Composition bug | Neuroendocrine breakdown | Systemic risk | Ecosystem collapse | System failure |
| L5 | Class action | Clinical syndrome | Market crash | Extinction event | Regime collapse |
| RECEPTOR SYSTEM | L1 · CHANNEL | L2 · CIRCUIT | L3 · NETWORK | L4 · SYSTEM | L5 · SYNDROME |
|---|---|---|---|---|---|
| DOPAMINE | D2R mutation | VTA fatigue | Mesolimbic desync | Reward cascade | Schizophrenia / Addiction |
| SEROTONIN | 5-HT transporter variant | Raphe circuit stress | Cortical-limbic desync | HPA axis dysregulation | Major depression / OCD |
| GABA | GABA-A subunit mutation | Inhibitory fatigue | E/I imbalance spread | Inhibitory collapse | Epilepsy / Anxiety disorder |
| GLUTAMATE | NMDAR hypofunction | LTP/LTD failure | Excitotoxic spread | Synaptic remodeling cascade | Psychosis / Alzheimer's |
| ACETYLCHOLINE | AChR mutation | Cholinergic circuit fatigue | Cortical attention desync | Basal forebrain degeneration | Dementia / Myasthenia gravis |
| OPIOID | MOR variant | PAG circuit sensitization | Pain network remodeling | Neuroimmune cross-talk failure | Chronic pain syndrome / OUD |
| CANNABINOID | CB1R variant | Endocannabinoid fatigue | Prefrontal-hippocampal desync | Neurodev. trajectory shift | CUD / Psychosis risk |
| SOFTWARE FACTOR | NEUROSCIENCE EQUIVALENT | ECONOMICS EQUIVALENT |
|---|---|---|
| shared_state | Shared neurotransmitter pools | Common counterparty exposure |
| monetary_path | Metabolic path (energy system) | Direct P&L impact |
| silent_failure | Preclinical phase (decades) | Hidden leverage |
| cumulative_effect | Progressive pathology | Compounding interest / debt |
| user_data | Memory / identity | Customer data / PII |
| external_dependency | Microbiome / environmental | Counterparty risk |
| async_operation | Temporal processing | Asynchronous settlement |
| recovery_required | Treatment required | Bailout required |
| undocumented | Idiopathic | Model risk |
| edge_case | Rare disease | Tail risk / black swan |